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What happens when disturbances in precision measurement instruments are indecipherable to physicists despite extensive review of the instruments and their outputs? How do physicists parse instrument outputs to discern sought-after signals from noise that originates from the surrounding natural and built environments, either masking or mimicking these desired signals? I argue that given the extreme sensitivity of the laser interferometers used by the Laser Interferometer Gravitational-Wave Observatory (LIGO) to detect minute length deformations caused by gravitational waves, physicists reconceptualized their traditional laboratory spaces to include the surrounding natural and built environments. Discerning signal from noise in instruments operating close to their low noise floors necessitate an epistemic shift that combines the laboratory with the surrounding natural and built environments beyond its walls through the epistemic space of the “expanded laboratory environment.” 

The Event Horizon Telescope (EHT) has led to the first images of a supermassive black hole, revealing the central compact objects in the elliptical galaxy M87 and the Milky Way. Proposed upgrades to this array through the next-generation EHT (ngEHT) program would sharply improve the angular resolution, dynamic range, and temporal coverage of the existing EHT observations. These improvements will uniquely enable a wealth of transformative new discoveries related to black hole science, extending from event-horizon-scale studies of strong gravity to studies of explosive transients to the cosmological growth and influence of supermassive black holes. Here, we present the key science goals for the ngEHT and their associated instrument requirements, both of which have been formulated through a multi-year international effort involving hundreds of scientists worldwide.